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From Asheville, NC to Cherohala Skyway:
Follow US 74 west for approximately 70 miles, and then turn north onto US 129. Take US 129 to Robbinsville, NC. Merge onto NC-143. Follow NC-143 for 12 miles to the beginning of the Cherohala Skyway at Santeetlah Gap.
From Knoxville, TN to Cherohala Skyway:
Take I-75 southwest to Sweetwater. Get on TN-68 and go south-west to Tellico Plains. Take TN-165 through Tellico Plains to where the byway begins.
From Chattanooga, TN to Cherohala Skyway:
Take I-24 east to I-75. Follow I-75 northeast to Sweetwater. Get on TN-68 and go southeast to Tellico Plains. Take TN-165 through Tellico Plains to where the byway begins.
Scenic drive from I-75, Cleveland Exit #20.
Take Cleveland Exit #20 from I-75 and follow Hwy. 64 E along the Ocoee River and the Ocoee Scenic Byway to Copperhill. Take Hwy. 68 N through Coker Creek and on to Tellico Plains.
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